Elevated inflammatory responses and targeted therapeutic intervention in a preclinical mouse model of ataxia-telangiectasia lung disease

Abstract Ataxia-telangiectasia (A-T) is an autosomal recessive, multisystem disorder characterized by cerebellar degeneration, cancer predisposition, and immune system defects.A major cause of mortality in A-T patients is severe pulmonary disease; however, the underlying causes of the replacement lid lung complications are poorly understood, and th

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Effects of AMF- and PGPR-root inoculation and a foliar chitosan spray in single and combined treatments on powdery mildew disease in strawberry

Trials were carried out using, as a root inoculants, mixed Glomus spp.(G.mossae, G.caledonium, and G.fasiculatum) and Bacillus subtilis FZB24, and the plant activator N, O-carboxymethyl chitosan applied as a foliar spray.The treatments were applied singly and in combinations, on strawberry plants grown out of season in a greenhouse.Both fruit yield

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In vitro and ex vivo modeling of enteric bacterial infections

ABSTRACTEnteric bacterial infections contribute substantially to global disease burden and mortality, particularly in the developing world.In vitro 2D monolayer cultures have provided critical insights into the fundamental virulence mechanisms of a multitude of pathogens, including Salmonella enterica serovars Typhimurium and Typhi, Vibrio cholerae

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